A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/113 (2006.01)
Patent
CA 2386782
Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
L'invention concerne des compositions nanoparticulaires bioadhésives, comprenant des particules d'agents actifs et un ou plusieurs stabilisateurs de surface cationiques. Ces stabilisateurs de surface cationiques préviennent l'agrégation des nanoparticules et augmentent la bioadhésion des nanoparticules sur des substrats biologiques, tels que les insectes, les dents, les os, les ongles, la chitine, les plumes, les écailles, les muqueuses, la peau, les cheveux, les tissus de la plante, etc. Ces particules peuvent être des composés pharmaceutiquement actifs (des composés médicamenteux destinés aux hommes ou aux animaux, par exemple), des produits chimiques agricoles (pesticides, herbicides, engrais, et analogues), des agents cosmétiques, des produits de consommation (agents colorants, arômes, ou parfums), ou d'autres matières qui interagissent avec des substrats biologiques. De plus, l'invention concerne des procédés destinés à la préparation et à l'utilisation de ces compositions nanoparticulaires bioadhésives.
Bosch H. William
Cooper Eugene R.
Mcgurk Simon L.
Elan Pharma International Ltd.
Fetherstonhaugh & Co.
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