Bioartificial liver system using bioreactor packed with gel...

Details Bioartificial liver system using bioreactor packed with gel... Bioartificial liver system using bioreactor packed with gel...

A - Human Necessities

61

F

A61F 2/02 (2006.01)

Patent

CA 2681798

The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.

La présente invention concerne un système de foie bioartificiel qui comprend un bioréacteur à lit fixe contenant des billes de gel renfermant des hépatocytes d'un animal, un réservoir de plasma et une chambre de sortie, ledit réservoir de plasma étant situé plus en hauteur que le bioréacteur, un filtre de ventilation en contact avec l'atmosphère étant placé en haut du réservoir de plasma qui est lui-même relié directement à la chambre de sortie par l'intermédiaire d'une ligne de connexion. Le système selon l'invention remplit de manière satisfaisante les fonctions essentielles du foie sans les problèmes liés à la détérioration des billes de gel ou à l'effet de canalisation.

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