Bioartificial pancreas

Details Bioartificial pancreas Bioartificial pancreas

A - Human Necessities

61

K

A61K 35/39 (2006.01) A61F 2/02 (2006.01) C12N 11/04 (2006.01)

Patent

CA 2140554

An implantable bioartificial pancreas device (1) having an islet chamber (5) coontaining glucose responsive and insulin-sec- reting islets of Langerhans or similar hormone secreting cells, the islet chamber (5) having baffle means (60) inside thereof to as- sist in even distribution of the islets in the chamber, one or more vascularizing chambers (10) open to surrounding tissue, a semi- permeable membrane (25) between the islet and vascularizing chambers that allows passage of small molecules including insulin, oxygen and glucose and does not allow passage of agents of the immune system such as white cells and antibodies, the vasculariz- ing chambers containing a growth factor soaked fibrous or foam matrix (30) having a porosity of about 40 to 95 %, the matrix providing small capillary growth and preventing the blood from clotting in the-lower chamber.

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