Bioassay system including optical detection apparatuses, and...

Details Bioassay system including optical detection apparatuses, and... Bioassay system including optical detection apparatuses, and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2703177

A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.

Système d'essai biologique, pouvant comprendre plusieurs appareils de détection optique, chacun comportant un substrat à détecteur lumineux, et un site lieur formé sur ce détecteur, ledit site étant traité pour la fixation de la biomolécule sur lui; le site considéré est proche du détecteur mais espacé par rapport à lui d'une distance inférieure ou égale à 100 micromètres. Le détecteur collecte la lumière émise depuis la biomolécule dans un angle solide supérieur ou égal à 0,8 SI stéradian. L'appareil de détection optique peut encore comprendre une source de lumière d'excitation formée sur le substrat de manière à établir une source lumineuse permettant d'exciter un fluorophore fixé à la biomolécule.

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