Bioavailable chelates of creatine and essential metals

Details Bioavailable chelates of creatine and essential metals Bioavailable chelates of creatine and essential metals

C - Chemistry, Metallurgy

07

C

C07C 279/14 (2006.01) A23L 1/30 (2006.01) A23L 1/304 (2006.01) A23L 2/52 (2006.01) A61K 31/198 (2006.01) A61P 3/02 (2006.01)

Patent

CA 2378106

A chelate comprised of creatine bonded to an essential mineral selected from the group consisting of Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se and Mn to form a heterocyclic ring. Preferably, the metal is Mg, but Ca, Zn, Fe, Cr and Mn are also preferred. The creatine chelates of the present invention are capable of being absorbed in the stomach or intestines via active transport without substantial metabolism of the chelate. In other words, the creatine ligand is protected by the metal from undergoing cyclization in the acidic environment of the stomach and the metal is made more bioavailable due to the presence of the creatine ligand.

L'invention concerne un chélate comprenant de la créatine liée à un minéral essentiel sélectionné parmi le groupe contenant Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se et Mn pour former un noyau hétérocyclique. De préférence, le métal est Mg, mais Ca, Zn, Fe, Cr et Mn sont aussi préférés. Les chélates de créatine de la présente invention peuvent être absorbés dans l'estomac ou les intestins par transport actif sans métabolisme important du chélate. En d'autres termes, le métal protège le ligand de créatine d'une cyclisation dans l'environnement acide de l'estomac et le métal est rendu plus biodisponible du fait de la présence du ligand de créatine.

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