Bioavailable formulations of heterocyclic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/443 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2677649

The present invention relates to bioavailable pharmaceutical formulations of heterocyclic compounds, such as such as N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8- methanesulfonamido-dibenzo[b,d]furan-l-carboxamide (oglemilast) and pharmaceutically acceptable salts thereof, to processes for their preparation and to methods of treatment using the same. The present invention also relates to substantially pure amorphous forms of heterocyclic compounds, such as oglemilast. The invention is particularly directed to bioavailable pharmaceutical oral dosage forms containing amorphous oglemilast.

L'invention concerne des formulations pharmaceutiques biodisponibles de composés hétérocycliques tels que le composé N-(3,5-dichloropyrid-4-yl)-4-difluorométhoxy-8- méthanesulfonamido-dibenzo[b,d]furan-l-carboxamide (oglemilast) et des sels pharmaceutiquement acceptables de celui-ci, des procédés de préparation de ces formulations et des méthodes de traitement utilisant celles-ci. L'invention concerne aussi des formes amorphes sensiblement pures de composés hétérocycliques tels que l'oglemilast. L'invention concerne en particulier des formes galéniques orales biodisponibles contenant l'oglemilast amorphe.

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