Bioceramic compositions

Details Bioceramic compositions Bioceramic compositions

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61F 2/28 (2006.01) A61F 2/30 (2006.01) A61K 9/20 (2006.01) A61L 27/00 (2006.01) A61L 27/12 (2006.01) A61L 27/38 (2006.01) A61L 27/42 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2268156

The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. the invention is useful for both medical and veterinary applications.

L'invention se rapporte à une phosphate de calcium du type hydroxy apatite synthétique à faible cristallinité (PCA), contenant un agent biologiquement actif et/ou des cellules (de préférence, des cellules de formation ou de dégradation tissulaire). Les compositions proposées dans la présente invention peuvent avoir de nombreuses applications in vivo et in vitro, y compris l'apport de médicaments (par exemple, au système nerveux central ou à des sites osseux, intramusculaires, sous-cutanés, interpéritonéaux et oculaires), la croissance de tissus (de préférence, des os et du cartilage) et l'augmentation osseuse; l'invention concerne également des méthodes de diagnostic d'états pathologiques par analyse de la capacité des cellules isolées d'un hôte de former des tissus. L'invention porte en outre sur des méthodes permettant de préparer des véhicules d'administration de médicaments, de modifier des caractéristiques desdits véhicules et de libérer des agents biologiquement actifs dans un site. L'invention concerne finalement des systèmes de culture cellulaire in vitro et des substances d'encapsulation de cellules. Cette invention peut avoir des applications médicales et vétérinaires.

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