C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
324/26
C12M 1/40 (2006.01) C12M 1/34 (2006.01) C12Q 1/00 (2006.01) G01N 33/48 (2006.01)
Patent
CA 1260538
ABSTRACT BIOCHEMICAL DETECTOR The present invention relates to a device for use in the detection, in a liquid sample, of a predetermined analyte with is reactive under predetermined enzyme catalysed conditions so as to produce at least one of a proton and hydrogen peroxide. The device comprises an electrically conducting polymer element 2 having spaced apart connections 9 to an electrical circuit means 12 for directly or indirectly detecting changes in electrical resistance in the element 2. The polymer 2 contains conjugatable monomer units and is permeable to protons and where said analyte under said enzyme catalyzed conditions produces hydrogen peroxide, to hydrogen peroxide. The polymer 2 further has an electrical conductivity which is variable according to the amount of protons or hydrogen peroxide in contact therewith, and an enzyme support element 4 containing at least one enzyme and any cofactor(s) required in the predetermined enzyme-catalyed conditions, in an analyte permeable substantially non-conducting medium and also has a first face 5 in contact with the polymer element 2 and a second face 6 disposable in contact with the liquid sample. The present invention also provides a method of detecting a predetermined analyte in a liquid sample comprising the steps of contacting the liquid sample with the second face 6 of the enzyme support element 4 of the device and measuring the change in resistance between the connection means 9.
532453
Pethrick Richard A.
Suckling Colin J.
Gowling Lafleur Henderson Llp
University Of Strathclyde
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