Biochemical synthesis of 1,4-butanediamine

Details Biochemical synthesis of 1,4-butanediamine Biochemical synthesis of 1,4-butanediamine

C - Chemistry, Metallurgy

12

P

C12P 13/00 (2006.01) C12N 9/10 (2006.01) C12N 9/88 (2006.01)

Patent

CA 2571528

The invention relates to a process for biochemical synthesis of 1,4- butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N- acetylglutamate formation.

L'invention concerne un procédé de synthèse biochimique de 1,4-butanediamine dans un micro-organisme présentant un niveau accru d'activité ornithine décarboxylase (activité ODC accrue) comparé au niveau natif de l'activité d'ornithine décarboxylase, le micro-organisme présentant également une activité accrue de formation de N-acétylglutamate comparée au niveau natif d'activité de formation de N-acétylglutamate dans le micro-organisme, et dans lequel la 1,4-butanediamine produite dans le micro-organisme est excrétée dans un bouillon de fermentation puis elle est récupérée dudit bouillon de fermentation. L'invention concerne également des vecteurs, des plasmides et des hôtes portant une activité ODC accrue correspondante ainsi qu'une activité accrue de formation de N-acétylglutamate.

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