A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/51 (2006.01) A61K 38/28 (2006.01) A61K 38/40 (2006.01) A61K 38/42 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C07K 14/05 (2006.01) C07K 14/16 (2006.01) C12N 11/14 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2174244
A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without denaturing the BRP. BRPs which may be attached include ligand-receptor pairs, enzyme-substrate pairs, drug-receptor pairs, catalyst-reactant pairs, toxin-ligand pairs, absorbant-absorbate pairs and adsorbant-adsorbate pairs. Also disclosed are biologically active compositions made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them. The compositions may further include an exterior targeting membrane which provides selective targeting to specific receptors. In addition, biologically active compositions for use in gene therapy and other transfection procedures are disclosed. The compositions are composed of nanocrystalline core particles which are coated with a layer that is designed to allow attachment of transfection agents (DNA/RNA segments or antisense fragments) without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting of the transfection agents to specific cell receptors.
L'invention concerne une composition à activité biologique qui comprend des particules noyaux ou des surfaces qui sont recouvertes d'une couche favorisant la fixation de paires à réaction biochimique (BRP) sans les dénaturer. Les BRP susceptibles d'être fixées comprennent les paires ligand-récepteur, les paires enzyme-substrat, les paires médicament-récepteur, les paires catalyseur-réactant, les paires toxine-ligand, les paires absorbant-absorbat et les paires adsorbant-adsorbat. L'invention concerne en outre des compositions à activité biologique composées de particules noyaux biodégradables recouvertes d'une couche destinée à favoriser la fixation d'agents à activité biologique sans les dénaturer. Ces compositions peuvent également contenir une membrane extérieure de ciblage qui confère un ciblage sélectif aux récepteurs spécifiques. L'invention concerne par ailleurs des compositions à activité biologique qui s'utilisent en thérapie génique, ainsi que d'autres procédés de transfection. Ces compositions comprennent des particules noyaux nanocristallines qui sont recouvertes d'une couche destinée à favoriser la fixation d'agents de transfection (segments d'ADN/d'ARN et fragments anti-sens) sans les dénaturer. Ces compositions peuvent en outre contenir une membrane extérieure de ciblage qui confère un ciblage sélectif des agents de transfection aux récepteurs de cellules spécifiques.
Gelman Andrew
Hnatyszyn H. James
Kossovsky Nir
Rajguru Samir
Sponsler Edward
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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