Biocidic medical devices, implants and wound dressings

Details Biocidic medical devices, implants and wound dressings Biocidic medical devices, implants and wound dressings

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61L 15/46 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2688624

The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.

La présente invention concerne un dispositif médical sélectionné dans un groupe constitué de dispositifs médicaux, d'implants et de pansements, comprenant au moins un puits ou une source de protons non soluble (PSS). Ce dispositif médical convient pour tuer des cellules cibles vivantes (LTC) ou pour dérègler des processus intracellulaires vitaux et/ou des interactions intercellulaires de LTC lors de la mise en contact. La PSS comprend, entre autres choses, (i) une source ou un puits de proton offrant une capacité de tampon, et (ii) un moyen fournissant une conductivité de protons et/ou un potentiel électrique. La PSS dérègle efficacement l'homéostase pH et/ou l'équilibre électrique à l'intérieur du volume confiné de la LTC et/ou dérègle des interactions intracellulaires vitales des LTC tout en préservant efficacement le pH de l'environnement des LTC.

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