C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 89/00 (2006.01) A61L 24/10 (2006.01) A61L 31/04 (2006.01) C09J 189/06 (2006.01)
Patent
CA 2172906
Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.
L'invention concerne des compositions à base de collagène utiles dans l'attachement de tissus ou l'attachement de tissus à des matériaux d'implant synthétique. Les compositions comprennent du collagène croisé au moyen d'un polymère hydrophile synthétique activé de façon multifonctionnelle. Une composition particulièrement préférée comprend du collagène fibrillaire, un agent de désassemblage de fibre et un polymère hydrophile synthétique activé de façon multifonctionnelle. L'invention porte sur des méthodes d'utilisation des compositions pour assurer l'attachement d'un tissu natif à la surface d'un autre tissu natif, un tissu non natif ou un implant synthétique. L'invention porte également sur des méthodes d'utilisation des compositions pour empêcher la formation d'adhésions chirurgicales.
Chu George H.
Delustro Frank A.
Harner Carol F. H.
Rao Prema R.
Rhee Woonza M.
Angiodevice International Gmbh
Battison Williams Dupuis
Collagen Corporation
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