Biocompatible compositions as carriers or excipients for...

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A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2449202

This invention refers to biocompatible carbohydrate polymers such as modified polysaccharides (e.g. chitosan, alginate), associated with milk protein (e.g. caseinate and/or whey proteins) designed to carry bioactive agents. The formulations may be used in various delivery systems including beads, tablets, microencapsulating agents and coatings for oral dosage forms, implants for subcutaneous devices and films for topic administration and food protection. These formulations present improved chemical resistance and exert their activity for prolonged time into gastro-intestinal tract (GIT) and blood circulation as well as for preserving food qualities over long period. The association of modified chitosan, modified alginate with milk proteins results in a stabilized structure able to control the release of drugs, bacteria, bacteriocines, enzymes, nutraceutics, etc. into enteric, topic or systemic route.

Polymères hydrates de carbone biocompatibles, tels que des polysaccharides modifiés (par ex. chitosane, alginate), associés à des protéines du lait (par ex. caséinate et / ou protéines lactosériques), et destinés à servir de support pour des agents bioactifs. Ces compositions peuvent être utilisées dans divers systèmes d'administration, dont des granules, des comprimés, des agents de microencapsulation et des revêtements pour des formes posologiques orales, des implants pour des dispositifs sous-cutanés et des films pour l'administration locale et la protection des aliments. Ces compositions présentent une résistance chimique améliorée et déploient leur activité pendant une période prolongée dans le tractus gastro-intestinal et la circulation sanguine, ainsi que pour préserver la qualité de produits alimentaires sur de longues périodes. L'association de chitosane modifié ou d'alginate modifié et de protéines du lait permet d'obtenir une structure stabilisée capable de réguler la libération de médicaments, de bactéries, de bactériocines, d'enzymes, de nutriceutiques, etc. par voie intestinale, locale ou systémique.

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