Biocompatible compounds for pharmaceutical drug delivery...

A - Human Necessities – 61 – K

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A61K 47/34 (2006.01) A61K 9/12 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61M 15/00 (2006.01)

Patent

CA 2279522

Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula -[X-R1-C(O)]- wherein each R1 is an independently selected organic group that links the -X- group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.

L'invention concerne des procédés, composés et formulations médicinales dans lesquels on utilise des polymères biocompatibles pour l'apport d'un médicament, notamment pour solubiliser, stabiliser et/ou procurer une libération prolongée de médicament à partir de systèmes topiques, implantables et d'inhalation. Beaucoup de ces procédés, composés et formulations médicinales sont appropriés à une inhalation orale et/ou nasale, et à une utilisation de polymères de la formule -[X-R<1>-C(O)]- dans laquelle chaque R<1> représente un groupe organique, choisi indépendamment et qui lie le groupe -X- au groupe carbonyle, chaque X représentant indépendamment oxygène, soufre ou azote caténaire.

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