Biocompatible container and method for in situ production of...

A - Human Necessities – 61 – K

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167/114, 204/91.

A61K 35/14 (2006.01) A61M 1/36 (2006.01)

Patent

CA 1264031

ABSTRACT OF THE DISCLOSURE The present invention discloses the effect of ultra- violet (UV) radiation on platelet concentrates collected in a plastics container, particularly in a polypropylene bag. Samples irradiated at 310 nm for 30 minutes at a dose of 774 J/M2 show no loss of platelet function as determined by ADP, collagen, or ristocetin-induced aggregation. Lymphocytes isolated from irradiated units are unable to act as responders or stimulators in a mixed lymphocyte reaction. The invention provides a device and a method of UV irradiation of platelet concentrates resulting in transfusible cell suspension unable to evoke immunological response while retaining normal platelet function.

498979

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