Biocompatible crosslinked hydrogels, drug-loaded hydrogels...

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 65/00 (2006.01) A61K 9/06 (2006.01) A61K 47/48 (2006.01) A61L 15/60 (2006.01) A61L 31/14 (2006.01)

Patent

CA 2722092

Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

Les compositions d'hydrogel selon l'invention sont formées par mélange d'un tétraméthylméthane substitué par un ou plusieurs polyéthylène glycols, chaque substituant polyéthylène glycol étant, en outre, indépendamment substitué par un ou plusieurs groupes électrophiles, et d'un tétraméthylméthane substitué par un ou plusieurs polyéthylène glycols, chaque substituant polyéthylène glycol étant, en outre, indépendamment substitué par un ou plusieurs groupes nucléophiles. Des procédés de préparation des hydrogels ci-dessus sont également décrits. Les compositions d'hydrogel selon l'invention peuvent, en outre, comprendre des agents pharmaceutiques, tels que des analgésiques ou des anesthésiques locaux. Des procédés pour occlure une plaie, prévenir les adhérences post-chirurgicales, et réduire la douleur post-chirurgicale au moyen desdits hydrogels sont également décrits.

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