Biocompatible crosslinked polymers

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 101/14 (2006.01) A61K 9/10 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61L 24/06 (2006.01) A61L 27/18 (2006.01) A61L 27/34 (2006.01) A61L 27/52 (2006.01) A61L 31/06 (2006.01) A61P 41/00 (2006.01) C08J 3/075 (2006.01) C08J 3/24 (2006.01) C08K 5/17 (2006.01) C08K 5/3415 (2006.01)

Patent

CA 2353642

Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

L'invention concerne des polymères réticulés biocompatibles, ainsi que leurs procédés de préparation et d'utilisation. Ces procédés consistent à former les polymères réticulés biocompatibles à partir de précurseurs, solubles dans l'eau, porteurs de groupes électrophiles et nucléophiles capables d'une réaction et d'une réticulation in situ. L'invention concerne également des procédés permettant de rendre les polymères réticulés biocompatibles obtenus biodégradables ou non, ainsi que des procédés permettant de réguler la vitesse de dégradation. Les réactions de réticulation précitées peuvent être réalisés in situ sur les organes ou les tissus ou à l'extérieur du corps. Parmi les applications relatives à ces polymères réticulés biocompatibles et à leurs précurseurs, on peut citer la libération contrôlée de médicaments, la prévention d'adhérences post-opératoires, le revêtement de dispositifs médicaux tels que les greffes vasculaires, les pansements et les substances chirurgicales d'étanchéité.

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