Biocompatible dialysis fluids containing icodextrins

Details Biocompatible dialysis fluids containing icodextrins Biocompatible dialysis fluids containing icodextrins

A - Human Necessities

61

M

A61M 1/28 (2006.01) A61K 31/718 (2006.01) A61M 1/14 (2006.01)

Patent

CA 2510788

Glucose polymer-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The glucose polymer-based solution preferably includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the glucose polymer-based solution to be mixed prior to infusion into a patient. The glucose polymer-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

L'invention concerne des solutions à base de polymères de glucose et des méthodes de fabrication de celles-ci, lesdites solutions pouvant être utilisées au cours d'une thérapie médicale, par exemple une thérapie de dialyse. La solution à base de polymères de glucose contient, de préférence, une première solution contenant de l'icodextrine à un pH d'environ 1,5 à environ 5,0 et une solution tampon à un pH d'environ 7,0 à 12,0, élaborées et disposées de manière à permettre à la solution à base de polymères de glucose d'être mélangée avant d'être perfusée chez un patient. Les solutions à base de polymères de glucose de la présente invention peuvent être mises au point avec un pH physiologique et des produits de dégradation minimale du glucose.

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