Biocompatible fleece for hemostasis and tissue engineering

Details Biocompatible fleece for hemostasis and tissue engineering Biocompatible fleece for hemostasis and tissue engineering

A - Human Necessities

61

L

A61L 31/04 (2006.01) A61L 15/26 (2006.01) A61L 15/42 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 26/00 (2006.01) A61L 27/18 (2006.01) A61L 27/38 (2006.01) A61L 27/56 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01)

Patent

CA 2438047

A porous, water-absorbing fleece is made from crosslinkable biocompatible and biodegradable macromers. A solution of the macromers is frozen and vacuum- dried through lyophilization. The "fleece" formed by lyophilization is then crosslinked, for example by heat and/or and initiator of crosslinking. The resulting crosslinked material is highly water absorbent, readily swelling to at least its size before lyophilization, but retains macroporosity as well as the microporosity of a gel. Porosity and strength of the fleece can be controlled by initial polymer concentration and extent of crosslinking. The fleece materials can be used in different embodiments for applications in medicine and tissue engineering.

Cette invention concerne un molleton poreux, absorbant l'eau, que l'on obtient à partir de macromères réticulables biocompatibles et biodégradables. Une solution de macromères est congelée et séchée sous vide par lyophilisation. Le "molleton" formé par lyophilisation est ensuite réticulé, notamment par la chaleur et/ou au moyen d'un initiateur de réticulation. Le matériau réticulé ainsi obtenu possède un pouvoir élevé d'absorption de l'eau et gonfle facilement jusqu'à atteindre au moins sa taille avant lyophilisation, tout en conservant la macroporosité et la microporosité d'un gel. La porosité et la robustesse du molleton peuvent être déterminées par la concentration polymère initiale de l'ampleur de la réticulation. Les matériaux du molleton peuvent s'utiliser dans des modes de réalisation divers pour des applications médicales ou la formation de tissu par génie tissulaire.

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