Biocompatible hydroxyapatite formulations and uses therefor

Details Biocompatible hydroxyapatite formulations and uses therefor Biocompatible hydroxyapatite formulations and uses therefor

A - Human Necessities

61

K

A61K 47/02 (2006.01) A61F 2/02 (2006.01) A61K 38/18 (2006.01) A61K 45/00 (2006.01) A61L 24/02 (2006.01) A61L 27/00 (2006.01) A61L 27/12 (2006.01) A61L 27/32 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2223596

A biocompatible hydroxyapatite formulation is provided. The formulation is precipitated from a mixture of a liquid phase, a bioactive or biocompatible additive which may be any of a number of bioreactive or other substances, and a base combination of calcium phosphate salts. The liquid phase and the additive may be combined to produce an augmented liquid phase, which is then mixed with the base salt combination. The additive is chosen to achieve a desired effect during administration of the formulation to a plant or animal. The additive is released into the surrounding physiological milieu and the hydroxyapatite component is resorbed.

L'invention porte sur une préparation biocompatible d'hydroxyapatite obtenue par précipitation d'un mélange d'une phase liquide, d'un additif biocompatible ou bioactif, qui peut être choisi parmi différents bioréacteurs ou d'autres substances, et une combinaison basique de sels phosphocalciques. La phase liquide et l'additif peuvent être combinés pour produire une phase liquide plus importante qui est ensuite mélangée avec la combinaison de sels basiques. L'additif est choisi pour permettre d'obtenir l'effet désiré lors de l'administration de la préparation à un végétal ou à un animal. L'additif est libéré dans le milieu physiologique environnant et l'hydroxyapatite est résorbée.

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