Biocompatible, low protein adsorption affinity matrix

Details Biocompatible, low protein adsorption affinity matrix Biocompatible, low protein adsorption affinity matrix

B - Operations, Transporting

01

J

B01J 20/26 (2006.01) G01N 33/545 (2006.01)

Patent

CA 2061510

ABSTRACT OF THE DISCLOSURE Affinity matrices useful for the chromatography and immobilization of biological materials and the method of preparing and using the same are disclosed. The affinity supports are based on hydrated poly- urethane polymers which have been activated to provide a means for covalently attaching a variety of bioaffinity agents. The hydrated polymer matrices are characterized by their biocompatibility and resistance to nonspecific protein adsorption. Preferably, the prepolymers used to prepare the hydrated polymers are isocyanate-capped oxyethylene-based diols or polyols, at least 75% of said diols and polyols having a molecular weight of 7000 to about 30,000.

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