C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 65/332 (2006.01) A61K 31/78 (2006.01) A61K 38/18 (2006.01) A61P 17/02 (2006.01) A61P 19/08 (2006.01)
Patent
CA 2345787
A new oligomer based on alternating fumaric acid and polyethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic group. Further, the OPF may be cross-linked using radical polymerization in the presence of either a chemical or photo initiator. A cross-linked OPF gel has a swelling behavior that is tunable dependent on the molecular weight of PEG. A cross- linkable PEG macromer, as exemplified by oligo(PEG fumarate), has unsaturated double bonds, for example in the fumaryl groups, along its macromolecular chain that allows for the preparation of hydrogels with tailored structure and properties.
Jo Seongbong
Mikos Antonios G.
Deeth Williams Wall Llp
Wm. Marsh Rice University
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