Biocompatible medical articles and process for their production

A - Human Necessities – 61 – L

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61L 33/00 (2006.01) A61L 29/08 (2006.01) A61L 31/10 (2006.01)

Patent

CA 2399756

An article of metal, glass, ceramics or plastics having a surface for contact with tissue or with circulating blood, has a surface coating of an organopolysiloxane and heparin, in which coating the organopolysiloxane is adherent to the surface of the article and has cationic groups that form ionic bonds with anionic groups of the heparin. The surface for contact with circulating blood may be an interior surface of a cannula or tubing or of a blood oxygenator or it may be a working surface of a blood filter. The polymer may be poly-[dimethylsiloxane - co - methyl-(3-hydroxypropyl)siloxane] - graft - poly(ethylene glycol) [3-(trimethylammonio) propyl chloride] ether. A method is also provided for forming a coated article as aforesaid, said method comprising contacting said surface with a solution in a volatile organic solvent of an organopolysiloxane and with heparin, the organopolysiloxane being adherent to the surface of the article and having cationic groups that form ionic bonds with the anionic groups of the heparin, and removing said volatile solvent.

L'invention porte sur un article de métal, de verre, de céramique ou de plastique présentant une surface devant être en contact avec les tissus ou le sang circulant revêtue d'organopolysiloxane et d'héparine, l'organopolysiloxane adhérant à la surface de l'article et présentant des groupes cationiques formant des liaisons ioniques avec les groupes anioniques de l'héparine. La surface en contact avec le sang circulant peut être la surface intérieure d'une canule ou d'un tubage ou d'un oxygénateur du sang, ou la surface de travail d'un filtre sanguin. Le polymère peut être un poly-[diméthylsiloxane - co - méthyl-(3-hydroxypropyl)siloxane] à greffe d'éther de - poly(éthylène glycol) [3-(triméthylammonio) propyl chlorure]. L'invention porte également sur un procédé de formation d'un article revêtu tel que mentionné supra consistant à mettre en contact ladite surface avec une solution dans un solvant organique volatile d'organopolysiloxane et avec l'héparine, l'organopolysiloxane adhérant à la surface de l'article et présentant des groupes cationiques formant des liaisons ioniques avec les groupes anioniques de l'héparine, puis à éliminer ledit solvant volatile.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Biocompatible medical articles and process for their production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible medical articles and process for their production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible medical articles and process for their production will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1392508

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.