C - Chemistry – Metallurgy – 09 – J
Patent
C - Chemistry, Metallurgy
09
J
C09J 4/00 (2006.01) A61L 24/06 (2006.01) C08K 9/10 (2006.01) A61L 25/00 (1990.01)
Patent
CA 2120304
ABSTRACT OF THE DISCLOSURE A biocompatible monomer composition contains (A) at least one monomer of the formula: CHR=CXY wherein X and Y are each strong electron withdrawing groups, and R is H or, provided that X and Y are both cyano groups, a C1-C4 alkyl group; and (B) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger compound. The monomer is preferably an alpha-cyanoacrylate. The formaldehyde scavenger compound may be in microencapsulated or non- microencapsulated form. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together n vivo two surfaces, e.g., body tissues, includes (a) applying to at least one of the surfaces a composition containing 1) at least one monomer, preferably an alpha- cyanoacrylate, which forms a polymer whose ln vlvo biodeg- radation produces formaldehyde; and 2) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger; and (b) maintaining the surfaces in contact until the composition polymerizes.
Clark Jeffrey G.
Leung Jeffrey C.
Closure Medical Corporation
Smart & Biggar
LandOfFree
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