Biocompatible phase invertable proteinaceous compositions...

A - Human Necessities – 61 – L

Patent

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A61L 27/44 (2006.01) A61F 2/06 (2006.01) A61L 24/00 (2006.01) A61L 24/10 (2006.01) A61L 27/14 (2006.01) A61L 27/22 (2006.01) A61L 27/24 (2006.01) A61L 27/40 (2006.01) A61L 27/54 (2006.01) A61L 29/04 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2494295

Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross- linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a pasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross- linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

L'invention concerne des compositions protéiniques biocompatibles à inversion de phase ainsi que des méthodes de production et d'utilisation de ces compositions. Les compositions à inversion de phase de l'invention sont préparées par combinaison d'un substrat protéinique avec un agent de réticulation. Le substrat protéinique comprend une ou plusieurs protéines et un modificateur de l'adhésion, et peut également comprendre un ou plusieurs agents choisis parmi un plastifiant, un glucide ou un autre agent de modification. Dans certains modes de réalisation, l'agent de réticulation est un dialdéhyde traité thermiquement, et notamment un glutaraldéhyde traité thermiquement. L'invention concerne également des trousses utilisées dans la préparation desdites compositions. Ces compositions, ces trousses et ces systèmes trouvent une utilisation dans une pluralité d'applications différentes.

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