Biocompatible polymer film

C - Chemistry – Metallurgy – 08 – J

Patent

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Details

C08J 5/18 (2006.01) A61L 27/34 (2006.01) A61L 29/08 (2006.01) A61L 31/10 (2006.01) A61L 33/06 (2006.01) C08G 81/00 (2006.01) C09D 183/10 (2006.01)

Patent

CA 2312370

The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional -OH end groups and reacting the -OH ends with a conventional monomer or prepolymer of a film- forming polymer capable of reacting with -OH groups. Such reactions am exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The -OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.

Cette invention a trait à un film copolymère pouvant être appliqué sur un article de manière à former une surface ininterrompue à biocompatibilité améliorée et plus lisse que celle d'un article non traité de la sorte. Ce film copolymère est, d'ordinaire, formé à partir d'un polymère séquencé hydrophobe, tel qu'un polydiméthylsiloxane (PDMS) à groupes terminauxH, ces groupes terminaux étant mis à réagir avec un monomère ou un prépolymère conventionnel'un polymère filmogène capable de réagir avec des groupesOH. A titre d'exemple, il est utilisé, pour ces réactions, comme PDMS réactif, un copolymère triséquencé du type polyéactone-polysiloxane-polylactone (PL-PDMS-PL) ou des polyesters de silicone. Les groupesH des polylactones séquencés sont capables de réagir avec n'importe quel isocyanate dans un solvant approprié pour former un polymère possédant un PDMS incorporé à sa structure. On peut appliquer le film sur un article en utilisant n'importe quel moyen d'enduction, le mélange réactif étant dans un solvant, et en provoquant ensuite l'évaporation du solvant.

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