C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 101/16 (2006.01) C08J 3/20 (2006.01) C08J 3/24 (2006.01) C08J 5/18 (2006.01) C08J 9/28 (2006.01)
Patent
CA 2616865
Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.
L'invention concerne des compositions et des procédés de fabrication de polymères. Des compositions comprennent de nouveaux plastiques, notamment des films et des éléments en forme comprenant des matrices de polymère qui sont biologiquement compatibles et biodégradables. Ces plastiques peuvent comprendre des polymères dérivés de sources naturelles. Par ailleurs, ces plastiques conviennent dans des systèmes biologiques destinés à soigner des blessures, des implants, des stents, un apport et une encapsulation de médicament et dans d'autres applications. Les procédés de l'invention comprennent des processus de fabrication légers de façon que divers additifs, tels que des protéines biologiquement actives, des sucres, des lipides et d'autres additifs similaires puissent être incorporés dans la matrice de polymère sans perte subséquente de bioactivité durant le processus. Enfin, l'invention concerne des procédés de fabrication destinés à contrôler des propriétés mécaniques, telles que l'élasticité, la flexibilité et la porosité de ces plastiques.
Campbell Phil
Fisher Gregory W.
Kumta Prashant
Sipe David M.
Smith Jason
Carnegie Mellon University
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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