Biocompatible protein-based particles and methods thereof

Details Biocompatible protein-based particles and methods thereof Biocompatible protein-based particles and methods thereof

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 47/42 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2711001

The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein- based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder...) and organ(s) (e.g. bladder, lips, vagina, penis, urethra...). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.

La présente invention concerne des particules à base de protéines biocompatibles, ainsi que leurs procédés de préparation et d'utilisation. La présente invention concerne, plus précisément, des particules à base de protéines comprenant une matrice de protéine, une matrice d'étalement et/ou des matériaux inducteurs de biocoacervation issus d'une ou de plusieurs protéines biocompatibles purifiées associées à un ou à plusieurs solvants biocompatibles qui sont utilisés pour remplacer ou réparer des tissus et/ou des os dans le cadre de traitements de disques spinaux, d'articulations (par ex., genou, hanche, doigt, cheville, coude, épaule, etc.) et d'organes (par ex., vessie, lèvres, vagin, pénis, urètre, etc.). Dans différents modes de réalisation de l'invention, les particules à base de protéines comprennent un ou plusieurs agents pharmacologiquement actifs et/ou un ou plusieurs additifs.

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