A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61K 39/385 (2006.01)
Patent
CA 2716187
The present invention is directed to a bioconjugate vaccine, such as an O1- bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, D/E - X - N - Z - S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O1-bioconjugate in a bioreactor comprising a number steps.
L'invention concerne un vaccin bioconjugué tel qu'un vaccin Ol-bioconjugué, qui comprend: un vecteur de protéine comprenant un vecteur de protéine contenant au moins une séquence consensus, D/E - X - N - Z - S/T, dans laquelle X et Z peuvent être n'importe quel acide aminé naturel à l'exception de la proline; au moins un polysaccharide antigénique provenant d'au moins une bactérie pathogène, liée au vecteur de protéine; et éventuellement un adjuvant. Dans un autre aspect, l'invention concerne un procédé de production en plusieurs étapes d'un O1-bioconjugué dans un bioréacteur.
Fernandez Fabiana
Kowarik Michael
Wacker Michael
Wetter Michael
Glycovaxyn Ag
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
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