C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 13/00 (2006.01) A61K 47/48 (2006.01) A61K 49/06 (2006.01) B01J 31/18 (2006.01) C07D 259/00 (2006.01) C07H 23/00 (2006.01) C07J 43/00 (2006.01)
Patent
CA 2229799
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, such as ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Bioconjugués d'imitateurs de mimétiques à faible poids moléculaire de superoxyde-dismutase (S.O.D.) représentés par la formule (I) dans laquelle R, R', R¿1?, R'¿1?, R¿2?, R'¿2?, R¿3?, R'¿3?, R¿4?, R'¿4?, R¿5?, R'¿5?, R¿6?, R'¿6?, R¿7?, R'¿7?, R¿8?, R'¿8?, R¿9?, R'¿9?, X, Y, Z et n sont tels que définis dans la description. Ces substances s'avèrent bénéfiques comme agents thérapeutiques dans le traitement de pathologies inflammatoires et des troubles tels que les lésions ischémiques/de perfusion répétée, les accidents cérébrovasculaires, l'athérosclérose, et dans toutes les autres formes de destructions ou de lésions tissulaires induites par oxydation.
Aston Karl W.
Henke Susan L.
Lennon Patrick J.
Neumann William L.
Riley Dennis P.
Monsanto Company
Osler Hoskin & Harcourt Llp
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