C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/00 (2006.01) C07C 2/02 (2006.01) C07C 2/50 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01) C10M 107/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2277159
This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules, such as oligonucleotides and proteins, using cycloaddition reactions, such as the Diels-Alder reaction or 1,3-dipolar cycloadditions. Included in the invention are the novel bioconjugated macromolecules that can be prepared according to the method of the invention.
La présente invention concerne une nouvelle méthode de conjugaison de macromolécules dans d'autres entités moléculaires. Plus spécifiquement, cette invention concerne une méthode de conjugaison ou de dérivation de macromolécules telles que des oligonucléotides et des protéines, par des réactions de cycloaddition, telles que la réaction de Diels-Alder, ou des cycloadditions 1,3-dipolaires. L'invention concerne en outre les nouvelles macromolécules bioconjuguées pouvant être préparées selon la méthode de l'invention.
Eaton Bruce
Gold Larry
Hill Ken
Mcgee Danny
Pieken Wolfgang
Proligo Llc
Sim & Mcburney
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