Biodegradable alpha-2 agonist polymeric implants and...

A - Human Necessities – 61 – K

Patent

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A61K 9/00 (2006.01) A61F 2/16 (2006.01) A61K 47/34 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2743837

Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

La présente invention concerne des implants intra-oculaires biocompatibles comprenant un agoniste de récepteur adrénergique alpha-2 et un polymère associé à lagoniste de récepteur adrénergique alpha-2 pour faciliter la libération de lagoniste de récepteur adrénergique alpha-2 dans un il pendant une durée prolongée. Lagoniste de récepteur adrénergique alpha-2 peut être associé à une matrice de polymère biodégradable, telle quune matrice de deux polymères biodégradables. Les implants peuvent être placés dans un il pour traiter une ou plusieurs affections oculaires, telles quune vasculopathie oculaire ou le glaucome, comprenant la réduction dune pression intra-oculaire élevée.

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