Biodegradable bioabsorbable material for clinical practice...

A - Human Necessities – 61 – L

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A61L 31/04 (2006.01) A61L 17/10 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 27/22 (2006.01) A61L 27/58 (2006.01) A61L 31/14 (2006.01)

Patent

CA 2428640

Bio-absorbable polymers such as vascular stent and suture thread for use as materials for clinical practice have almost definite dynamic properties such as tensile strength and degradation rate for absorption. When the dynamic properties thereof are elevated, therefore, the bio-absorbable polymers turn fragile, involving slower degradation rate. When the degradation rate is elevated, further, the dynamic properties are deteriorated. Disadvantageously, such bio-absorbable polymers have limited purposes for use and limited sites for use. Thus, copolymerization of bio-absorbable monomers with a cyclic depsipeptide to form a copolymer of the ring-opened and copolymerized depsipeptide can allow the adjustment of the dynamic properties and degradation rate of the resulting copolymer depending on the content of the depsipeptide.

Ces polymères bioabsorbables utilisés en médecine, notamment comme stents et articles de suture, conservent des propriétés dynamiques quasiment constantes (résistance à la traction, etc.) ainsi que quasiment la même vitesse de dégradation causée par l'absorption. Si l'on souhaite améliorer ces propriétés dynamiques, ces matériaux se fragilisent et la vitesse de dégradation est réduite. Si l'on souhaite accélérer la vitesse de dégradation, ce sont alors les propriétés dynamiques qui se détériorent et il en découle que les fins d'utilisation et les sites d'utilisation se restreignent. De ce fait, dans le cadre de cette invention, on copolymérise un polymère bioabsorbable à l'aide d'un depsipeptide cyclique, afin d'obtenir un copolymère possédant l'ouverture de cycles d'un depsipeptide copolymérisé. Il est, de ce fait, possible de maîtriser les propriétés dynamiques ainsi que la vitesse de dégradation en fonction du contenu du depsipeptide.

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