Biodegradable cationic polymer gene transfer compositions...

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 77/12 (2006.01) A61K 48/00 (2006.01) C08L 75/02 (2006.01) C08L 75/04 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2709412

The invention provides biodegradable, cationic compositions based on cationic a-amino acid-containing PEA, PEUR and PEU polymers for use in preparation of non-viral gene transfer compositions. In the invention gene transfer compositions a poly nucleic acid is condensed with the polymer to form a soluble unit wherein the electrical charge of the poly nucleic acid is neutralized by the polymers. The invention gene transfer compositions can be used to transfect target cells by contact with the target cells.

L'invention concerne des compositions cationiques biodégradables basées sur des polymères PEA, PEUR et PEU contenant un acide a-aminé cationique pour une utilisation dans la préparation de compositions de transfert de gène non virales. Dans les compositions de transfert de gène de l'invention, un acide polynucléique est condensé avec le polymère pour former une unité soluble dans laquelle la charge électrique de l'acide polynucléique est neutralisée par les polymères. Les compositions de transfert de gène de l'invention peuvent être utilisées pour transfecter des cellules cibles par contact avec les cellules cibles.

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