Biodegradable colloidal particles for pulmonary applications...

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 9/51 (2006.01) A61K 47/48 (2006.01) C08F 216/06 (2006.01) C08G 63/06 (2006.01)

Patent

CA 2545877

The invention relates to a composition consisting of a bio-degradable, water- soluble comb polymer, based on a polyol backbone with side chains that carry amino groups and a stabiliser in the form of at least one negatively charged organic base, which can be a Lewis or Brönsted base, or a corresponding acid of said base, which can be a Lewis or Brönsted acid. There can be an excess or deficiency of the acidic groups of the stabilisers in relation to the primary, secondary or tertiary amino groups of the comb polymers or an excess or deficiency of the basic groups in relation to the quaternary amino groups of the comb polymers, in such a way that the colloid particles have a positive or negative zeta potential. Colloid particles of this type are particularly suitable for the pulmonary application of acidic or negatively charged pharmaceutical active agents.

L'invention concerne une composition constituée d'un polymère en peigne biodégradable, soluble dans l'eau, présentant une structure polyol à chaînes latérales portant des groupes amino, et d'au moins une base organique chargée négativement, pouvant être une base de Lewis ou de Brönsted, ou de l'acide correspondant pouvant être un acide de Lewis ou de Brönsted. Les groupes acides des stabilisateurs sont en excès ou en défaut par rapport aux groupes amino primaires, secondaires ou tertiaires des polymères en peigne, ou les groupes basiques sont en excès ou en défaut par rapport aux groupes amino quaternaires des polymères en peigne, de telle manière que les particules colloïdales présentent un potentiel zêta positif ou négatif. De telles particules colloïdales sont notamment adaptées à l'application pulmonaire d'agents pharmaceutiques acides ou chargés négativement.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Biodegradable colloidal particles for pulmonary applications... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biodegradable colloidal particles for pulmonary applications..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable colloidal particles for pulmonary applications... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1762443

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.