Biodegradable compositions for the controlled release of...

A - Human Necessities – 61 – K

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A61K 9/50 (2006.01) A61F 2/02 (2006.01) A61F 13/02 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2338031

Pharmaceutical compositions that enable the release of a physiologically active substance over a prolonged period of time following administration to a patient are described. The pharmaceutical compositions are provided by encapsulation of a physiologically active substance into a matrix comprising biodegradable polymers and lipids. The rate of release of the physiologically active substance from the pharmaceutical composition is controlled by varying the ratio of the polymer to the lipid. The compositions can be stored in an aqueous suspension or as a solid dosage form. The physiologically active substances include small molecules, peptides, proteins, nucleic acids and vaccines. The biodegradable polymers include homopolymers, or random or block copolymers. The lipids include phospholipids, cholesterol and glycerides.

On décrit des compositions pharmaceutiques qui permettent de libérer une substance biologiquement active sur une durée prolongée après l'administration à un patient. Les compositions pharmaceutiques sont formées par encapsulation d'une substance physiologiquement active dans une matrice comprenant des lipides et des polymères biodégradables. La vitesse de libération de la substance physiologiquement active contenue dans la composition pharmaceutique est contrôlée par le biais du rapport polymère-lipide. Les compositions peuvent être incorporées dans une suspension aqueuse ou bien adopter une forme posologique solide. Les substances physiologiquement actives peuvent être des petites molécules, des peptides, des protéines, des acides nucléiques et des vaccins. Les polymères biodégradables sont des homopolymères ou bien des copolymères séquencés ou aléatoires. Les lipides incluent les phospholipides, le cholestérol et les glycérides.

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