Biodegradable cross-linked cationic multi-block copolymers...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/87 (2006.01) A61K 9/10 (2006.01) A61K 47/34 (2006.01) C08G 73/04 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2585974

A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks is linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

L'invention concerne un copolymère multibloc cationique réticulé biodégradable de polyéthylénimine linéaire (LPEI). Les blocs LPEI sont reliés ensemble par des lieurs hydrophiles avec une liaison disulfure biodégradable. L'invention concerne également des procédés de fabrication associés. Ledit copolymère multibloc cationique réticulé biodégradable peut également contenir des groupements fonctionnels pendants qui sont, de préférence, des ligands récepteurs, des agents de perméation, des agents endosomolytiques, des séquences de localisation nucléaire, des peptides endosomolytiques sensibles au pH, des colorants chromogènes ou fluorescents.

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