Biodegradable hydrogel matrices for the controlled release...

Details Biodegradable hydrogel matrices for the controlled release... Biodegradable hydrogel matrices for the controlled release...

A - Human Necessities

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A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/26 (2006.01) A61K 9/52 (2006.01) A61K 9/70 (2006.01) A61K 47/42 (2006.01)

Patent

CA 1338958

A biodegradable hydrogel matrix is provided, useful for the controlled release of pharmacologically active agents. The matrix is formed by cross-linking a proteinaceous component and a polysaccharide or mucopolysaccharide, and then loading a selected drug therein. By varying temperature, ionic strength, and the composition of the hydrogel matrix, one can control degradation kinetics, the degree of uptake of a particular pharmacologically active agent, and the overall timed release profile.

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