Biodegradable immunomodulatory formulations and methods for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2402247

The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.

L'invention concerne de nouvelles compositions et des procédés d'immunomodulation des individus. L'immunomodulation est effectuée par administration de complexes polynucléotide/micro-porteur immunomodulateurs (IMP/MC). Ces complexes (IMP/MC) peuvent être ou non liés de manière covalente, et présentent un polynucléotide comprenant au moins une séquence immunostimulatrice liée à un micro-porteur ou à un nano-porteur biodégradable.

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