Biodegradable implant precursor

Details Biodegradable implant precursor Biodegradable implant precursor

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61C 13/08 (2006.01) A61F 2/00 (2006.01) A61K 6/00 (2006.01) A61K 9/00 (2006.01) A61K 47/34 (2006.01) A61L 27/16 (2006.01) A61L 27/18 (2006.01) A61L 27/50 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) A61L 27/58 (2006.01) A61L 31/14 (2006.01) B29C 41/08 (2006.01) B29C 41/12 (2006.01) B29C 67/06 (2006.01)

Patent

CA 2117394

The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.

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