A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
167/328, 400/705
A61L 27/00 (2006.01) A61F 2/02 (2006.01) A61K 9/00 (2006.01) A61K 47/34 (2006.01) A61L 15/44 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 24/06 (2006.01) A61L 26/00 (2006.01) A61L 27/16 (2006.01) A61L 27/18 (2006.01) A61L 27/26 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61F 2/30 (2006.01)
Patent
CA 1340694
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
613406
Cowsar Donald R.
Dunn Richard L.
English James P.
Vanderbilt David P.
Atrix Laboratories Inc.
Finlayson & Singlehurst
Southern Research Institute
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