Biodegradable matrix and methods for producing same

Details Biodegradable matrix and methods for producing same Biodegradable matrix and methods for producing same

C - Chemistry, Metallurgy

08

L

167/170, 18/27

C08L 89/06 (2006.01) A61K 9/22 (2006.01) A61K 9/70 (2006.01) A61L 15/16 (2006.01) A61L 15/32 (2006.01) A61L 15/44 (2006.01) A61L 15/64 (2006.01) A61L 27/24 (2006.01) A61L 27/56 (2006.01) A61L 27/58 (2006.01)

Patent

CA 1295796

Abstract of the Disclosure There are disclosed processes for preparing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and III collagens is freeze dried to form a collagen-based sponge which is contacted with a cross- linking agent selected from the group consisting of a carbodiimide or a succinimidyl active ester to form an intermediate collagen-based matrix which is subsequently subjected to conditions of severe dehydration to form the collagen-based matrix in sponge or sheet form. In another embodiment, a collagen-based sponge or sheet is first subjected to conditions of severe dehydration followed by contacting the thus formed intermediate collagen-based matrix with a carbodiimide crosslinking compound to form the collagen-based matrix in sponge or sheet form. In still another embodiment of the present invention the crosslinking agent is admixed with the collagen-based material prior to formation of the collagen-based sponge or sheet followed by processing steps of severe dehydration. In a particularly preferred form of the invention, a carrier compound is incorporated during processing to form a collagen-based matrix in sponge or sheet form impregnated with a carrier compound wherein the carrier compound is selected from the group consisting of types IV and V collagen, fibronectin, laminin, hyaluronate, proteoglycan, epidermal growth factor, platelet derived growth factor, angiogenesis factor, antibiotic, antifungal agent, spermacidal agent, enzyme and enzyme inhibitor. 32/3/16/84 marn

477358

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