Biodegradable metal-chelating polymers and vaccines

Details Biodegradable metal-chelating polymers and vaccines Biodegradable metal-chelating polymers and vaccines

C - Chemistry, Metallurgy

08

L

C08L 77/12 (2006.01) A61K 47/34 (2006.01) C08J 3/12 (2006.01)

Patent

CA 2723721

The invention provides metal-chelating poly (ether amide) polymers useful in preparation of polymer compositions for delivering a variety of cargo molecules, such as bioactive agents. In solution metal ions and cargo molecules, such as vaccine epitopes, that include metal avid amino acids can be loaded into the polymer compositions and held in a non-covalent complex. Nanoparticles of such polymer compositions can also be prepared directly from the solution.

La présente invention concerne des polymères de poly(éther amide) chélatants métallifères utiles pour la préparation de compositions polymères permettant de produire une diversité de molécules cargos, telles que des agents bioactifs. En solution, les ions métalliques et les molécules cargos, telles que des épitopes de vaccins, qui comprennent des acides aminés présentant une avidité pour le métal, peuvent être chargés dans les compositions polymères et maintenues dans un complexe non covalent. Les nanoparticules de telles compositions polymères peuvent également être directement préparées à partir de la solution.

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