A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 47/34 (2006.01) A61P 5/00 (2006.01) C07K 14/505 (2006.01) C07K 14/575 (2006.01)
Patent
CA 2387229
The present invention relates to a composition for the sustained release of biologically active, novel erythropoietin stimulating protein (NESP), and improved methods of forming said composition. The composition comprises polymeric microparticles within which particles of NESP have been dispersed. The improved method utilizes a cosolvent mixture to effect more efficient and rapid removal of residual polymer solvents during any drying process.
L'invention concerne une composition permettant la libération prolongée d'une nouvelle protéine biologiquement active stimulant l'érythropoïétine (NESP), et des procédés améliorés permettant de fabriquer cette composition. La composition comprend des microparticules polymères à l'intérieur desquelles des particules de la nouvelle protéine ont été dispersées. Le procédé amélioré consiste à utiliser un mélange de cosolvants de manière à retirer plus rapidement et plus efficacement des restes de solvants polymères au cours d'un processus de séchage.
Burke Paul
French Donna L.
Herberger John
Klumb Lisa
Murphy Keith
Amgen Inc.
Gowling Lafleur Henderson Llp
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