Biodegradable microspheres as a carrier for macromolecules

Details Biodegradable microspheres as a carrier for macromolecules Biodegradable microspheres as a carrier for macromolecules

A - Human Necessities

61

K

167/164, 117/46.

A61K 9/16 (2006.01)

Patent

CA 1309657

ABSTRACT A method for preparing biodegradable micro- spheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble mono- vinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.

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