Biodegradable nerve guides

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/12 (2006.01) A61B 17/03 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2713214

The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydro-gel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides.

La présente invention porte sur des compositions et des procédés de préparation de guides nerveux greffés en hydrogel pour une régénérescence de nerfs périphériques. En particulier, la présente invention porte sur les guides nerveux et sur des procédés de préparation de guides nerveux greffés en hydrogel avec des facteurs neurotrophes encapsulés et un réseau de nanofibres revêtant la surface interne du guide. La présente invention porte également sur des procédés de réparation de nerfs périphériques utilisant ces guides nerveux greffés en hydrogel.

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