C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 77/12 (2006.01) A61K 31/785 (2006.01) A61P 41/00 (2006.01) C08L 67/00 (2006.01) C08L 75/02 (2006.01) C08L 75/04 (2006.01)
Patent
CA 2690878
The present invention provides adhesion barrier compositions based on a solution of at least one of a biodegradable polyester amide (PEA), polyester urethane (PEUR), or polyester urea (PEU) polymers, dissolved in a biocompatible solvent. The compositions can be applied to a tissue surface, such as in open surgery, as a viscous liquid which forms an adhesive film upon being sprayed or painted onto the tissue surface. Alternatively, the composition can be applied to the tissue surface as a preformed solid layer or double layer (either porous or non-porous) that adheres to the tissue surface. In open surgery, the invention adhesion barrier compositions are used to separate opposing tissue surfaces or tissue-organ surfaces while injured tissues heal, for example in the abdomen or pelvis. The present invention provides adhesion barrier compositions based on a solution of at least one of a biodegradable polyester amide (PEA), polyester urethane (PEUR), or polyester urea (PEU) polymers, dissolved in a biocompatible solvent. The compositions can be applied to a tissue surface, such as in open surgery, as a viscous liquid which forms an adhesive film upon being sprayed or painted onto the tissue surface. Alternatively, the composition can be applied to the tissue surface as a preformed solid layer or double layer (either porous or non-porous) that adheres to the tissue surface. In open surgery, the invention adhesion barrier compositions are used to separate opposing tissue surfaces or tissue-organ surfaces while injured tissues heal, for example in the abdomen or pelvis.
La présente invention concerne des formules de barrières adhésives basées sur une solution d'au moins l'un des membres du groupe constitué par les polymères biodégradables suivants : polyester-amide (PEA), polyester-uréthane (PEUR) et polyester-urée (PEU), dissous dans un solvant biocompatible. Les formules peuvent être appliquées sur une surface tissulaire, par exemple en chirurgie ouverte, sous forme d'un liquide visqueux qui forme un film adhésif lorsqu'il est vaporisé ou peint sur la surface tissulaire. De façon alternative, la formule peut être appliquée à la surface tissulaire sous forme d'une couche solide préformée ou d'une double couche solide (poreuse ou non) qui adhère à la surface tissulaire. En chirurgie ouverte, les formules de barrières adhésives selon l'invention sont employées pour séparer des surfaces de tissus opposés ou des surfaces tissu-organe pendant la guérison des tissus endommagés, par exemple au niveau de l'abdomen ou du pelvis.
Carpenter Kenneth W.
Zhang Huashi
Medivas Llc
Smart & Biggar
LandOfFree
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