Biodegradable polymer matrices for sustained delivery of...

A - Human Necessities – 61 – K

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A61K 47/30 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/50 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/245 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2144407

An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation.

L'invention concerne un système biodégradable de libération régulée qui consiste en une matrice polymère contenant un anesthésique local destiné à être administré de manière prolongée, ainsi qu'un procédé de fabrication de ladite matrice. Les polymères et le procédé de fabrication utilisés pour former ladite matrice d'anesthésiant local en polymère sont sélectionnés selon leurs profils de dégradation: libération de l'anesthésique local de manière linéaire et régulée de préférence sur une période de deux semaines et dégradation in vivo avec une demi-vie de moins de six mois, de préférence de deux semaines, afin d'éviter l'inflammation localisée. Dans un autre mode de réalisation, un agent anti-inflammatoire peut être incorporé dans le polymère avec l'anesthésique local afin d'empêcher l'inflammation.

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