Biodegradable terephthalate polyester-poly(phosphate)...

C - Chemistry – Metallurgy – 08 – G

Patent

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C08G 63/692 (2006.01) A61K 9/16 (2006.01) A61L 17/00 (2006.01) A61L 17/12 (2006.01) A61L 26/00 (2006.01) A61L 27/00 (2006.01) A61L 27/18 (2006.01)

Patent

CA 2285903

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula (I): wherein R is a divalent organic moiety; R' is an aliphatic, aromatic or heterocyclic residue; x is 1; and n is 0- 5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

L'invention concerne des polymères biodégradables de térephthalate comprenant les unités monomères récurrentes de la formule (I) dans laquelle R représente une fraction organique divalente; R' représente un reste aliphatique, aromatique ou hétérocyclique; x est ? 1 et n vaut entre 0 et 5,000. Le polymère biodégradable est compatible avant et pendant la biodégradation. L'invention concerne également des procédés de préparation des polymères, des compositions contenant les polymères et des substances biologiquement actives, des articles obtenus à partir de ces compositions et utilisés pour être implantés ou injectés dans le corps, ainsi que des procédés de libération régulée de substances biologiquement actives utilisant ces polymères.

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