Biodegradable terephthalate polyester-poly(phosphonate) and...

A - Human Necessities – 61 – K

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Details

A61K 47/34 (2006.01) A61K 9/16 (2006.01) A61L 17/10 (2006.01) A61L 24/04 (2006.01) A61L 31/06 (2006.01) A61P 35/00 (2006.01) C08G 63/692 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2345240

The invention comprises biodegradable terephthalate polymers comprising the recurring monomeric units shown in formula (I), wherein R is a divalent organic moiety; R' is hydrogen, an aliphatic, aromatic or heterocyclic residue; x is >= 1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Medical and drug delivery devices comprising the polymers and a biologically active substance, articles useful for implantation or injection into the body, fabricated using the polymers, and methods for controlled release of biologically active substances using the polymers, are also described.

Cette invention a trait à des polymères biodégradables de térephthalate comprenant les unités monomères récurrentes correspondant à la formule (I). Dans cette formule, R représente une fraction organique divalente, R' représente un hydrogène, un reste aliphatique, aromatique ou hétérocyclique, x >= 1 et la valeur de n est comprise entre 3 et 7,500. Ce polymère biodégradable, qui est assez pur pour être biocompatible, est capable de former des restes biocompatibles après biodégradation. L'invention concerne également des dispositifs médicaux et des dispositifs de libération de médicament comportant les polymères et une substance biologiquement active, des articles, pouvant être implantés ou injectés dans le corps, obtenus à partir de ces compositions ainsi que des procédés de libération régulée de substances biologiquement actives utilisant ces polymères.

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